The Biophysical Chemistry Laboratory of the University of Tehran, under the supervision of Professor Ali A. Moosavi-Movahedi, Professor at the University of Tehran, Fellow of the Academy of Sciences, I.R. Iran, President of Iran Society of Biophysical Chemistry presents a brief report on the 2026 Nobel Prize in Physiology or Medicine and its profound connection with biophysics. The 2026 Nobel Prize recognizes Peter Hegemann, Georg Nagel, and Karl Deisseroth for pioneering work that established optogenetics, a powerful method for controlling the activity of living cells, particularly neurons, with light. Hegemann and Nagel discovered light-sensitive proteins known as channelrhodopsins in the unicellular alga Chlamydomonas. Deisseroth subsequently introduced the corresponding gene into neurons, demonstrating that light could precisely activate or inhibit neural activity. At the molecular level, optogenetics provides a remarkable example of biophysics in action: light interacts with a protein, the protein controls an ion channel, ion movement generates electrical signals, and these signals alter neuronal function. The significance of this discovery lies in the fact that a small protein can serve as an intermediary between light, physics, genetics, and brain function. It is a beautiful example of the power of biophysics in understanding life. For a great discovery, more important than the name of a discipline is the ability to see the connections between disciplines. The report also highlights a 2022 article published in Basic Sciences Letter of the Academy of Sciences, which identified 39 Nobel Prizes related to biophysics,24 in Chemistry, 3 in Physics, and 12 in Physiology or Medicine. With the 2026 Nobel Prize, these total reaches 40.